TY - CHAP M1 - Book, Section TI - Chapter 16. Zollinger-Ellison Syndrome (Gastrinoma) A1 - Lew, Edward A2 - Greenberger, Norton J. A2 - Blumberg, Richard S. A2 - Burakoff, Robert PY - 2012 T2 - CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e AB - Peptic ulcer disease, abdominal pain, and diarrhea are common presentations.Patients have marked gastric acid secretion arising from a gastrin-secreting non–β islet cell tumor.Multiple endocrine neoplasia syndrome type 1 (MEN 1) is present in ~20–25% of patients.Serum gastrin concentration >1000 pg/mL in combination with acidic stomach pH <2.0 is diagnostic.Up to 40% of patients have elevated serum gastrin levels that are <500 pg/mL and warrant a secretin test.Significant hypergastrinemia can occur with proton pump inhibitor use, Helicobacter pylori infection, or chronic atrophic gastritis and hypochlorhydria. SN - PB - The McGraw-Hill Companies CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=55957153 ER -