TY - CHAP M1 - Book, Section TI - Tuberculosis A1 - Gupta, Akash A1 - Jacobson, Karen R. A2 - Grippi, Michael A. A2 - Antin-Ozerkis, Danielle E. A2 - Dela Cruz, Charles S. A2 - Kotloff, Robert M. A2 - Kotton, Camille Nelson A2 - Pack, Allan I. PY - 2023 T2 - Fishman’s Pulmonary Diseases and Disorders, 6e AB - Tuberculosis (TB) is a severe and contagious disease caused by Mycobacterium tuberculosis complex (MTBC). Most often involving the lungs, TB is transmitted by cough, with an infectious dose of less than 10 bacteria.1 Case fatality rates in untreated active pulmonary TB approach nearly 60%.2 Starting in the 1940s, major medical advances brought effective treatment capable of curing the vast majority of clinical cases.3,4 TB continues to cause more than a million deaths worldwide every year. The morbidity and mortality burden of TB is unevenly distributed throughout the globe, disproportionately affecting those living in poverty and those from resource-limited settings.5 SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1195015383 ER -