TY - CHAP M1 - Book, Section TI - Eosinophilic Lung Diseases A1 - Cohn, Lauren A1 - Rochester, Carolyn L. A1 - Clark, Brian J. A2 - Grippi, Michael A. A2 - Antin-Ozerkis, Danielle E. A2 - Dela Cruz, Charles S. A2 - Kotloff, Robert M. A2 - Kotton, Camille Nelson A2 - Pack, Allan I. PY - 2023 T2 - Fishman’s Pulmonary Diseases and Disorders, 6e AB - Eosinophils cause lung disease when they release granule proteins, cytokines, arachidonic acid metabolites, superoxide anions, and metalloproteases and other mediators that cause tissue damage, lead to bronchial hyperresponsiveness, and further activate immunologic cascades that enhance inflammation. Pulmonary eosinophilia is a result of enhanced eosinophil development through eosinophil-lineage commitment and maturation in the bone marrow, recruitment into the lung from the circulation, and prolonged eosinophil survival. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1195007717 ER -