TY - CHAP M1 - Book, Section TI - Chemokines, Adipokines, and Growth Factors in the Lung A1 - Butler, Marcus W. A1 - McLoughlin, Paul A1 - Keane, Michael P. A2 - Grippi, Michael A. A2 - Antin-Ozerkis, Danielle E. A2 - Dela Cruz, Charles S. A2 - Kotloff, Robert M. A2 - Kotton, Camille Nelson A2 - Pack, Allan I. PY - 2023 T2 - Fishman’s Pulmonary Diseases and Disorders, 6e AB - The normal development of organ systems—including the lungs in utero, their subsequent maturation to adulthood, and maintenance of health throughout life—requires intricate signals to be exchanged among various tissues, capable of permitting diversity and adaptation in differing cellular and extracellular contexts, while being robust to onslaughts from ever-changing environmental stimuli. Among the mediators involved in such complex cellular signaling, and relevant in the setting of many pulmonary disorders, are chemokines and growth factors. There has been further complexity added with increasing recognition of adipose tissue as a source of systemic bioactive mediators, called adipokines, that impact on lung health. While some of these mediators are implicated in the development of disease states, they are more often than not also critical to tissue homeostasis and are challenging target systems for therapeutic manipulation. Nonetheless, we are now in an era of exciting developments in targeted biologic therapies that offer the potential for substantial progress in the fight against difficult-to-treat pulmonary disorders characterized by pathogenic processes including acute and chronic inflammation, fibrosis, vascular remodeling, and neoplasia. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1194947462 ER -