TY  - CHAP
M1  - Book, Section
TI  - Pharmacodynamics: Molecular Mechanisms of Drug Action
A1  - Manning, David R.
A1  - Blumenthal, Donald K.
A2  - Brunton, Laurence L.
A2  - Knollmann, Björn C.
PY  - 2023
T2  - Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 14th Edition
AB  - AbbreviationsAC:  adenylyl  cyclaseACE:  angiotensin-converting  enzymeACh:  acetylcholineAKAP:  A-kinase  anchoring  proteinAMPA:  α-amino-3-hydroxy-5-methyl-4-isoxazole  propionic  acidAMPK:  AMP-activated  protein  kinaseAngII:  angiotensin  IIANP:  atrial  natriuretic  peptideAP-1:  activator  protein-1  (transcription  factor)Apaf-1:  apoptotic  activating  protease  factor  1ATG:  autophagy  geneAT1R:  angiotensin  subtype  1  receptorBNP:  brain  natriuretic  peptideCaM:  calmodulinCAR:  constitutive  androstane  receptorCNP:  C-type  natriuretic  peptideCYP:  cytochrome  P450DAG:  diacylglycerolDHFR:  dihydrofolate  reductaseEC50:  half-maximally  effective  concentrationED50:  half-maximally  effective  doseEGF:  epidermal  growth  factoreNOS:  endothelial  NOS  (NOS3)EPAC:  exchange  protein  activated  by  cyclic  AMPER:  endoplasmic  reticulumFBP:  fructose  1,6-bisphosphateFXR:  farnesoid  X  receptorGABA:  γ-aminobutyric  acidGC:  guanylyl  cyclaseGEF:  guanine  nucleotide  exchange  factorGnRH:  gonadotropin-releasing  hormoneGPCR:  G  protein-coupled  receptorGRK:  GPCR  kinaseHMG-CoA:  hydroxymethylglutaryl–coenzyme  AHRE:  hormone  response  element5HT:  5-hydroxytryptamine  (serotonin)IFN:  interferonIL:  interleukiniNOS:  inducible  NOS  (NOS2)IP3:  inositol  1,4,5-trisphosphateJAK:  Janus  kinaseJNK:  c-Jun  N-terminal  kinaseKi:  affinity  of  a  competitive  antagonistKir:  inward  rectifying  K+  channelLD50:  half-maximal  lethal  doseLKB1:  liver  kinase  B1LXR:  liver  X  receptorMAPK:  mitogen-activated  protein  kinaseMLCK:  myosin  light  chain  kinasemTOR:  mechanistic  or  mammalian  target  of  rapamycin,  a  protein  kinasemTORC:  mechanistic  or  mammalian  target  of  rapamycin  complexNAM:  negative  allosteric  modulatorNE:  norepinephrineNF-κB:  nuclear  factor-κBNMDA:N-methyl-D-aspartatenNOS:  neuronal  NOSNO:  nitric  oxideNOS:  NO  synthaseNPR:  natriuretic  peptide  receptorNSAID:  nonsteroidal  anti-inflammatory  drugPAMP:  pathogen-associated  molecular  patternPDE:  cyclic  nucleotide  phosphodiesterasePAM:  positive  allosteric  modulatorPDGF:  platelet-derived  growth  factorPI3K:  phosphatidylinositol  3-kinasePIP2:  phosphatidylinositol  4,5-bisphosphatePK:  protein  kinase,  e.g.,  PKA,  PKB  (also  known  as  Akt),  PKCPLC:  phospholipase  CPPAR:  peroxisome  proliferator-activated  receptorPTB:  phosphotyrosine-bindingPXR:  pregnane  X  receptorRAR:  retinoic  acid  receptorRGS:  regulator  of  G  protein  signalingRhoGEF:  RhoA  guanine  nucleotide  exchange  factorRIP1:  receptor  interacting  protein  1ROCK:  Rho-associated  protein  kinaseRXR:  retinoid  X  receptorSERM:  selective  estrogen  receptor  modulatorsGC:  soluble  guanylyl  cyclaseSH2:  Src  homology  2SMAC:  second  mitochondria-derived  activator  of  caspaseSMN1:  survival  motor  neuron  proteinSTAT:  signal  transducer  and  activator  of  transcriptionTGF-β:  transforming  growth  factor  βTLR:  toll-like  receptorTNF-α:  tumor  necrosis  factor  αTNFR:  TNF-α  receptorTOR:  target  of  rapamycinTRAIL:  TNF-related  apoptosis-inducing  ligandTRP:  transient  receptor  potentialVEGF:  vascular  endothelial  growth  factorVSMC:  vascular  smooth  muscle  cell  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193226677
ER  -