TY  - CHAP
M1  - Book, Section
TI  - Pulmonary Alveolar Proteinosis
A1  - Fitzpatrick, Meghan E.
A1  - Prendergast, Niall T.
A1  - Rivera-Lebron, Belinda
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Pulmonary  alveolar  proteinosis  is  a  rare  disease  characterized  by  accumulation  of  lipoproteinaceous  material  within  alveolar  spaces.  The  condition  may  be  primary  (idiopathic)  or  secondary  (occurring  in  immunodeficiency;  hematologic  malignancies;  inhalation  of  mineral  dusts;  or  following  lung  infections,  including  tuberculosis  and  viral  infections).  Progressive  dyspnea  is  the  usual  presenting  symptom.  Chest  radiograph  shows  bilateral  alveolar  infiltrates,  and  chest  CT  features  a  characteristic  “crazy-paving”  that  refers  to  ground-glass  opacities  with  superimposed  interlobular  and  intralobular  septal  thickening.  The  diagnosis  is  based  on  demonstration  of  characteristic  findings  on  BAL  (milky  appearance  and  periodic  acid-Schiff  [PAS]-positive  lipoproteinaceous  material)  in  association  with  clinical  and  radiographic  features.  In  secondary  disease,  an  elevated  anti-GM-CSF  (anti-granulocyte-macrophage  colony-stimulating  factor)  titer  in  serum  or  BAL  fluid  is  highly  sensitive  and  specific.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193146275
ER  -