TY  - CHAP
M1  - Book, Section
TI  - Cystic Fibrosis
A1  - Fitzpatrick, Meghan E.
A1  - Prendergast, Niall T.
A1  - Rivera-Lebron, Belinda
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - ESSENTIALS  OF  DIAGNOSISAutosomal  recessive  disorder.Pulmonary  disease:  chronic  or  recurrent  productive  cough,  dyspnea,  and  wheezing;  recurrent  airway  infections  or  chronic  colonization  of  the  airways  with  H  influenzae,  P  aeruginosa,  S  aureus,  or  Burkholderia  cenocepacia;  bronchiectasis  and  scarring  on  chest  radiographs;  airflow  obstruction  on  spirometry.Extrapulmonary  disease:  sinus  disease  (chronic  sinusitis  and  nasal  polyposis);  GI  disease  (pancreatic  insufficiency,  recurrent  pancreatitis,  hepatobiliary  disease,  meconium  ileus,  and  distal  intestinal  obstruction);  genitourinary  problems  (absent  vas  deferens  and  male  infertility).Diagnosis:  sweat  chloride  concentration  >  60  mEq/L  on  two  occasions;  or  presence  of  two  disease-causing  mutations  in  the  cystic  fibrosis  transmembrane  conductance  regulator  (CFTR)  gene;  or  sweat  chloride  concentration  30–59  mEq/L  plus  one  disease-causing  mutation  in  CFTR  gene.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193145939
ER  -