TY  - CHAP
M1  - Book, Section
TI  - Disorders of Phosphorus Concentration
A1  - Arora, Nayan
A1  - Jefferson, J. Ashley
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Plasma  phosphorus  is  mainly  inorganic  phosphate  and  represents  a  small  fraction  (less  than  0.2%)  of  total  body  phosphate.  Important  determinants  of  plasma  inorganic  phosphate  are  renal  excretion,  intestinal  absorption,  and  shift  between  the  intracellular  and  extracellular  spaces.  The  kidney  is  the  most  important  regulator  of  the  serum  phosphate  level.  PTH  decreases  reabsorption  of  phosphate  in  the  proximal  tubule  while  1,25-dihydroxyvitamin  D  increases  reabsorption.  Renal  proximal  tubular  reabsorption  of  phosphate  is  decreased  by  hypertension,  corticosteroids,  metabolic  acidosis,  and  proximal  tubular  dysfunction  (as  in  Fanconi  syndrome).  Fibroblast  growth  factor  23  (FGF23)  is  a  potent  phosphaturic  hormone.  Intestinal  absorption  of  phosphate  is  facilitated  by  active  vitamin  D.  Cellular  phosphate  uptake  is  stimulated  by  various  factors  and  conditions,  including  alkalemia,  insulin,  epinephrine,  refeeding  syndrome,  hungry  bone  syndrome,  and  accelerated  cell  proliferation.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/23
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193125136
ER  -