TY  - CHAP
M1  - Book, Section
TI  - Antibiotic Prophylaxis of Surgical Site Infections
A1  - Cheng, Hugo Q.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - Surgical  site  infection  is  estimated  to  occur  in  roughly  4%  of  general  or  vascular  operations.  Although  the  type  of  procedure  is  the  main  factor  determining  the  risk  of  developing  a  surgical  site  infection,  certain  patient  factors  have  been  associated  with  increased  risk,  including  diabetes  mellitus,  older  age,  obesity,  smoking,  heavy  alcohol  consumption,  admission  from  a  long-term  care  facility,  and  multiple  medical  comorbidities.  For  most  major  procedures,  the  use  of  prophylactic  antibiotics  has  been  demonstrated  to  reduce  the  incidence  of  surgical  site  infections.  Substantial  evidence  suggests  that  a  single  dose  of  an  appropriate  intravenous  antibiotic—or  combination  of  antibiotics—administered  30–60  minutes  prior  to  skin  incision  is  as  effective  as  multiple-dose  regimens  that  extend  into  the  postoperative  period.  For  most  procedures,  a  first-generation  cephalosporin  (eg,  cefazolin  2  g  intravenously)  is  as  effective  as  later-generation  agents.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/17
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193124492
ER  -