TY - CHAP M1 - Book, Section TI - Adverse Drug Reactions A1 - Manno, Rebecca L. A1 - Yazdany, Jinoos A1 - Tarrant, Teresa K. A1 - Kwan, Mildred A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2023 T2 - Current Medical Diagnosis & Treatment 2023 AB - Prick skin testing for most low-molecular-weight drugs is not validated and is interpretable only if the test is positive at a nonirritating concentration. Testing for IgE-mediated allergy to penicillin (PCN) is validated; skin testing with the metabolic determinants of PCN has a high (more than 98%) negative predictive value. Referral of individuals with a listed PCN allergy to an allergist for evaluation is worthwhile because more than 90% have either lost sensitization or do not have a true PCN allergy. Such patients may then safely receive beta-lactam antibiotics, including penicillins and cephalosporins. Allergy testing to non-PCN drugs is more limited because it is either not standardized in practice or in reagent preparation, or the reaction may not be IgE-mediated; an allergist may provide guidance about the likelihood and severity of future exposures to determine whether re-challenging with the drug would be advisable. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1193126200 ER -