TY  - CHAP
M1  - Book, Section
TI  - Cephalosporins
A1  - Gruenberg, Katherine
A1  - Guglielmo, B. Joseph
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2023
T2  - Current Medical Diagnosis & Treatment 2023
AB  - The  cephalosporins,  structurally  related  to  the  penicillins,  consist  of  a  beta-lactam  ring  attached  to  a  dihydrothiazoline  ring.  Substitutions  of  chemical  groups  result  in  varying  pharmacologic  properties  and  antimicrobial  activities.  Type  1  allergic  cross-reactions  between  penicillins  and  cephalosporins  are  primarily  due  to  similarities  in  the  molecular  structure  of  the  R  side  chains;  for  example,  penicillin  and  cefoxitin  have  similar  R  side  chains;  ampicillin  and  cephalexin  share  similar  side  chains.  Consequently,  a  patient  with  a  type  1  reaction  to  penicillin  would  be  more  likely  to  experience  a  similar  reaction  with  cefoxitin  when  compared  with  cephalexin.  In  contrast,  a  patient  with  an  allergic  reaction  to  ampicillin  would  be  more  likely  to  have  a  reaction  to  cephalexin  than  cefoxitin.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1193121979
ER  -