TY - CHAP M1 - Book, Section TI - Epidemiology, Pathophysiology, and Treatment of Hypertension A1 - Hall, Michael E. A1 - Hall, John E. A1 - Whelton, Paul K. A2 - Fuster, Valentin A2 - Narula, Jagat A2 - Vaishnava, Prashant A2 - Leon, Martin B. A2 - Callans, David J. A2 - Rumsfeld, John S. A2 - Poppas, Athena PY - 2022 T2 - Fuster and Hurst's The Heart, 15e AB - Content UpdatePhase 2 KARDIA-2 TrialThe KARDIA-2 trial was a global, multicenter, phase 2, randomized, double-blind, placebo-controlled study designed to evaluate the safety and efficacy of zilebesiran compared with placebo among patients with uncontrolled hypertension. Zilebesiran is an investigational, biannually dosed, subcutaneously injected RNA interference agent that blocks production of angiotensinogen. Read More SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/09/09 UR - accessmedicine.mhmedical.com/content.aspx?aid=1207966522 ER -