TY - CHAP M1 - Book, Section TI - Drugs for Movement Disorders A1 - Stringer, Janet L. PY - 2022 T2 - Basic Concepts in Pharmacology: What You Need to Know for Each Drug Class, 6e AB - In Parkinson disease there is loss of the dopamine-containing neurons in the substantia nigra (Figure 22–1). These neurons normally project to the caudate putamen (one piece of the basal ganglia) where the dopamine inhibits firing of the cholinergic neurons. These cholinergic neurons form excitatory synapses onto other neurons that project out of the basal ganglia. The result of the loss of dopamine-containing neurons is that the cholinergic neurons are now without their normal inhibition. This is a bit like a car going down a hill without any brakes. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1187633886 ER -