TY - CHAP M1 - Book, Section TI - Tolerance & Autoimmune Disease A1 - Levinson, Warren A1 - Chin-Hong, Peter A1 - Joyce, Elizabeth A. A1 - Nussbaum, Jesse A1 - Schwartz, Brian PY - 2022 T2 - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 17e AB - Immune tolerance is the lack of responsiveness to a specific antigen that could otherwise elicit an immune response. The best example of antigen tolerance is a host’s normal absence of response for “self” antigens, while those same antigens might be considered “foreign” if transplanted to a different host. Because it applies to responses to antigens, tolerance is a feature of adaptive immunity, although certain antigen-presenting cells can have a tolerogenic effect on T cells. In this chapter, we will discuss how immune tolerance to “self” develops and what happens when that tolerance is broken, namely, autoimmune diseases develop. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1190865070 ER -