TY - CHAP M1 - Book, Section TI - Iron Overdose A1 - Smollin, Craig A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2022 T2 - Current Medical Diagnosis & Treatment 2022 AB - Iron is widely used therapeutically for the treatment of anemia and as a daily supplement in multiple vitamin preparations. Most children's preparations contain about 12–15 mg of iron (as sulfate, gluconate, or fumarate salt) per dose, compared with 60–90 mg in most adult-strength preparations. Iron is corrosive to the gastrointestinal tract and, once absorbed, has depressant effects on the myocardium and on peripheral vascular resistance. Intracellular toxic effects of iron include disruption of Krebs cycle enzymes. Carbonyl iron is a powdered form of elemental iron. It is not as irritating to the gastrointestinal tract as the iron salts and appears to be safer. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/18 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184179676 ER -