TY - CHAP M1 - Book, Section TI - Anticoagulants Overdose A1 - Smollin, Craig A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2022 T2 - Current Medical Diagnosis & Treatment 2022 AB - Warfarin and related compounds (including ingredients of many commercial rodenticides, the so-called superwarfarins such as brodifacoum, difenacoum, and related compounds) inhibit the normal clotting system by blocking hepatic synthesis of vitamin K–dependent clotting factors. After ingestion of “superwarfarins,” inhibition of clotting factor synthesis may persist for several weeks or even months after a single dose. Direct-acting oral anticoagulants (DOACs) include the direct thrombin inhibitor dabigatran and the factor Xa inhibitors apixiban, betrixaban, edoxaban, and rivaroxaban. Some of these, especially dabigatran, are largely eliminated by the kidney and may accumulate in patients with kidney dysfunction. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184179484 ER -