TY  - CHAP
M1  - Book, Section
TI  - Delayed Hypersensitivity
A1  - Yazdany, Jinoos
A1  - Manno, Rebecca L.
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
A2  - McQuaid, Kenneth R.
PY  - 2022
T2  - Current Medical Diagnosis & Treatment 2022
AB  - According  to  the  Gell  and  Coombs  classification,  type  IV  delayed  hypersensitivity  is  mediated  by  activated  T  cells,  which  accumulate  in  areas  of  antigen  deposition.  A  common  example  is  allergic  contact  dermatitis,  which  develops  when  a  low-molecular-weight  sensitizing  substance  serves  as  a  hapten  for  dermal  proteins,  becoming  a  complete  antigen.  Sensitized  T  cells  release  cytokines,  activating  macrophages  and  promoting  subsequent  dermal  inflammation;  this  typically  occurs  48–72  hours  after  contact.  Another  common  expression  of  delayed  hypersensitivity  is  drug  allergy  that  occurs  after  a  similar  process  and  that  often  results  in  maculopapular  or  morbilliform  exanthems.  T-cell–mediated  hypersensitivity  is  now  understood  to  involve  both  Th1  and  Th2  cells.  In  addition,  subsequent  inflammation  and  tissue  damage  occur  via  various  effector  cell  types,  including  monocytes,  eosinophils,  and  neutrophils.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/19
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1184193799
ER  -