TY - CHAP M1 - Book, Section TI - Systemic Sclerosis (Scleroderma) A1 - Yazdany, Jinoos A1 - Manno, Rebecca L. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2022 T2 - Current Medical Diagnosis & Treatment 2022 AB - ESSENTIALS OF DIAGNOSISLimited disease (CREST syndrome): skin thickening confined to face, neck, and distal extremities.Diffuse disease (20%): widespread thickening of skin, including truncal involvement, with areas of increased pigmentation and depigmentation.Raynaud phenomenon and antinuclear antibodies are present in virtually all patients.Systemic features: gastroesophageal reflux, gastrointestinal hypomotility, pulmonary fibrosis, pulmonary hypertension, renal involvement. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184193178 ER -