TY - CHAP M1 - Book, Section TI - Acquired Disorders of Coagulation A1 - Leavitt, Andrew D. A1 - Price, Erika Leemann A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2022 T2 - Current Medical Diagnosis & Treatment 2022 AB - Patients with antiphospholipid antibodies occasionally have antibody specificity to coagulation factor II (prothrombin) that accelerates factor II clearances and can lead to severe hypoprothrombinemia and bleeding. Mixing studies may or may not reveal presence of an inhibitor, as the antibody typically binds a non-enzymatically active portion of the molecule leading to accelerated clearance, but characteristically the PT is prolonged and levels of factor II are low. FFP should be administered to treat bleeding. Treatment is immunosuppressive. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184168651 ER -