TY - CHAP M1 - Book, Section TI - Cancer Prevention A1 - Pignone, Michael A1 - Salazar, René A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. A2 - McQuaid, Kenneth R. PY - 2022 T2 - Current Medical Diagnosis & Treatment 2022 AB - Cancer mortality rates continue to decrease in the United States; part of this decrease results from reductions in tobacco use, since cigarette smoking is the most important preventable cause of cancer. Primary prevention of skin cancer consists of restricting exposure to ultraviolet light by wearing appropriate clothing, and use of sunscreens. Persons who engage in regular physical exercise and avoid obesity have lower rates of breast and colon cancer. Prevention of occupationally induced cancers involves minimizing exposure to carcinogenic substances, such as asbestos, ionizing radiation, and benzene compounds. Chemoprevention has been widely studied for primary cancer prevention (see earlier Chemoprevention section and Chapter 39). Use of tamoxifen, raloxifene, and aromatase inhibitors for breast cancer prevention is discussed in Chapters 17 and 39. Hepatitis B vaccination can prevent hepatocellular carcinoma (HCC). Screening and treatment of hepatitis C is another strategy to prevent HCC (see Chapter 16); new recommendations have extended the population eligible for screening. The use of HPV vaccine to prevent cervical and possibly anal cancer is discussed earlier in this chapter. HPV vaccines may also have a role in the prevention of HPV-related head and neck cancers. The USPSTF recommends genetic counseling and, if indicated after counseling, genetic testing for women whose family or personal history is associated with an increased risk of harmful mutations in the BRCA 1/2 gene. Guidelines for optimal cancer screening in adults over the age of 75 are unsettled; thus, an individualized approach that considers differences in disease risk rather than chronological age alone is recommended. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1184155686 ER -