TY - CHAP M1 - Book, Section TI - Vaccine Decision-making and Vaccine Hesitancy A1 - Wagner, Abram L. A1 - Pinckney, Leah C. A1 - Zikmund-Fisher, Brian J. A2 - Boulton, Matthew L. A2 - Wallace, Robert B. PY - 2022 T2 - Maxcy-Rosenau-Last Public Health & Preventive Medicine, 16e AB - Negative attitudes toward vaccination are not a recent phenomenon. Medical and political leaders have had to respond to these attitudes for hundreds of years. The precursor to smallpox vaccination, variolation with smallpox inocula, was introduced from the Ottoman Empire into the United Kingdom by Lady Mary Montague in the first quarter of the eighteenth century.1 Within Europe and the New World, it quickly faced religious and philosophical objections suggesting variolation countered God’s will in determining who was sick and who was healthy. Pamphlets produced by political and religious leaders, such as Cotton Mather, were important in countering negative sentiments and popularizing the spread of variolation in the American colonies.2 SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1182675524 ER -