TY - CHAP M1 - Book, Section TI - Female Reproductive Toxicology A1 - Janssen, Sarah A1 - Shahbaz, Michael A2 - LaDou, Joseph A2 - Harrison, Robert J. PY - 2021 T2 - CURRENT Diagnosis & Treatment: Occupational & Environmental Medicine, 6e AB - The occurrence of adverse reproductive outcomes is of fundamental concern to the individuals and families affected. This is especially true if the individuals perceive that they are living or working in areas with potential exposure to hazardous agents over which they have little or no control. Concern has been fueled by incidents such as the contamination of fish with methyl mercury in Minamata Bay, Japan, which was caused by a release from a manufacturing plant. Consumption of the contaminated fish by pregnant women resulted in an epidemic of mental retardation, cerebral palsy, and developmental delay in their offspring. Use of polychlorinated biphenyl (PCB)–contaminated cooking oil in Taiwan resulted in intrauterine growth retardation and hyperpigmentation of the skin in infants of exposed women. Effects on that cohort continue to be uncovered today, including on offspring pubertal development. In recent years, there have been concerns about the reproductive effects of occupational exposure to solvents, pesticides, and video-display terminals or electromagnetic fields (EMFs). A new area of research has sprung up to identify and study chemicals that may act to disrupt the endocrine system, affecting both wildlife and humans. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180878677 ER -