TY - CHAP M1 - Book, Section TI - Erythrocyte Disorders as a Result of Toxic Agents A1 - Herrmann, Paul C. A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. PY - 2021 T2 - Williams Hematology, 10e AB - SUMMARYErythrocyte disorders can be caused by a wide variety of toxic agents. Whereas some erythrocyte toxins damage red blood cells through well-defined mechanisms, others have mechanisms that are incompletely defined or for which there is complexity involving multiple simultaneous pathways. The well-defined mechanisms include neocytolysis, damage from oxidation, damage to structural proteins, damage to erythrocyte membranes, and direct damage to metabolic pathways. Incompletely defined mechanisms are responsible for toxicity from nanoparticles and metals with broad biological activity spectra such as lead. A table of other toxins not specifically described in the text is included. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180482446 ER -