TY - CHAP M1 - Book, Section TI - METHOTREXATE A1 - Gugelmann, Hallam A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. PY - 2018 T2 - Poisoning & Drug Overdose, 7e AB - Methotrexate, or N-(4-{[(2,4-diamino-6-pteridinyl)methyl]-methylamino}benzoyl)-L-glutamic acid, is an antimetabolite chemotherapeutic agent that is also used for psoriasis, rheumatoid arthritis, systemic sclerosis, placenta accreta, and ectopic pregnancy. Most toxicity is caused by chronic oral overmedication. Inadvertent high-dose intrathecal, intravenous, and intramuscular methotrexate administration and acute intentional overdose have been reported. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1179991962 ER -