TY  - CHAP
M1  - Book, Section
TI  - Immune-Mediated Tissue Injury
A1  - Hamm, Rose
A1  - Carey, Joseph N.
PY  - 2021
T2  - Essential Elements of Wound Diagnosis
AB  - The  goal  of  the  immune  system  is  to  protect  the  body  from  anything  that  is  not  a  part  of  it,  from  germs  to  foreign  bodies  to  harmful  substances.  The  exquisite  process  of  immunology  begins  in  the  skin  with  cells  that  phagocytose  bacteria  (macrophages,  polymorphic  neutrophilic  lymphocytes),  cells  that  release  cytokines  (endothelial  cells,  activated  platelets,  neutrophils,  and  T-lymphocytes),  and  dendritic  cells  that  carry  antigens  from  the  injury  site  to  the  local  lymph  nodes  where  the  adaptive  immune  system  is  activated.1  If  the  immune  system  is  over-activated,  the  body  will  attack  itself  and  destroy  healthy  cells  and  tissues;  if  it  is  suppressed,  the  body  becomes  susceptible  to  microbes  that  are  normally  destroyed  and  therefore  it  develops  infections  more  easily.2  While  a  discussion  of  this  miraculous  process  is  beyond  the  scope  of  this  chapter,  it  is  important  to  recognize  that  both  the  up-  and  down-regulation  of  the  immune  system  and  its  processes  can  result  in  dermal  wounds,  or  they  can  impede  the  healing  of  existing  wounds  through  a  change  in  cellular  activity  or  as  a  result  of  the  medication  used  to  treat  the  disorder.  The  purpose  of  this  chapter  is  to  assist  the  clinician  in  recognizing  wounds  that  are  mediated  by  immune  disorders,  as  well  as  to  stress  the  importance  of  understanding  the  effects  of  medications  (e.g.  corticosteroids,  NSAIDs,  anti-rejection  medications,  and  other  immune-suppressors)  on  the  wound  healing  process,  in  which  case  collaboration  between  the  wound  care  clinician  and  the  immunologist  is  needed  to  manage  the  medications  in  such  a  way  that  wound  healing  is  optimized.  
SN  - 
PB  - McGraw Hill
CY  - New York, NY
Y2  - 2024/04/16
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1179739293
ER  -