TY - CHAP M1 - Book, Section TI - Gout A1 - Yokose, Chio A1 - Choi, Hyon K. A2 - Stone, John H. PY - 2021 T2 - Current Diagnosis & Treatment: Rheumatology, 4e AB - Caused by deposition of monosodium urate crystals due to longstanding hyperuricemia.Usually begins as an intermittent, acute mono- or oligoarthritis, especially of the first metatarsophalangeal joint.Flares typically become more frequent and involve more joints over time, in the absence of treatment.Diagnosed by evaluating joint fluid for monosodium urate crystals using polarized light microscopy.Extra-articular manifestations include subcutaneous tophi and renal stones.Flares of arthritis respond to anti-inflammatory drugs such as nonsteroidal anti-inflammatory drugs, colchicine, or glucocorticoids. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/04/24 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180198057 ER -