TY - CHAP M1 - Book, Section TI - Behçet Disease A1 - Gül, Ahmet A2 - Stone, John H. PY - 2021 T2 - Current Diagnosis & Treatment: Rheumatology, 4e AB - Recurrent oral and genital aphthous ulcers and bilateral posterior/panuveitis are the hallmarks of Behçet disease (BD). Other disease manifestations include pustular and nodular skin lesions, arthritis, thrombophlebitis affecting superficial and deep veins, arterial aneurysms, brainstem lesions, and gastrointestinal ulcers.Although similar mucocutaneous lesions can be seen in other inflammatory conditions, the ocular, vascular, and neurologic manifestations have distinctive features.A hyperinflammatory response to physical trauma such as hypodermic injections (the pathergy reaction) or to environmental triggers such as streptococcal antigens is a characteristic feature of the disease. Genetic polymorphisms contribute to this dysregulated immune response.There are no pathognomonic laboratory and clinical features of BD. Thus, the recognition of a combination of manifestations that are distinctive in their collective presence is necessary to establish the diagnosis.Treatment should be tailored to the patient’s individual disease features. Medications, such as colchicine, glucocorticoids, immunosuppressives, apremilast, and biologic agents, can be used both to control inflammatory flares and to prevent recurrences. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180197648 ER -