TY - CHAP M1 - Book, Section TI - Erythrocyte Antigens and Antibodies A1 - Lomas-Francis, Christine A2 - Kaushansky, Kenneth A2 - Prchal, Josef T. A2 - Burns, Linda J. A2 - Lichtman, Marshall A. A2 - Levi, Marcel A2 - Linch, David C. PY - 2021 T2 - Williams Hematology, 10e AB - SUMMARYBlood group antigens are structures on the outer surface of human red blood cells (RBCs) that can be recognized by the immune system of individuals who lack that particular structure. Identification of RBC antigens and antibodies is the basis of pretransfusion compatibility testing and the safe transfusion practices used today and provides insights into understanding the etiology of hemolytic disease of the fetus and the newborn. Biochemical and molecular studies have led to definition of the biologic functions of molecules expressing blood group antigens. These molecules play a critical role in susceptibility to infection by malarial parasites, some viruses, and bacteria. Alteration of RBC antigen expression is associated with many molecular backgrounds, and some play a role in the clinical manifestations of certain diseases. Erythrocytes, far from being inert containers of hemoglobin, are active in a variety of physiologic processes. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1178757034 ER -