TY - CHAP M1 - Book, Section TI - Erythema Nodosum A1 - Hardin, J. Matthew A2 - Knoop, Kevin J. A2 - Stack, Lawrence B. A2 - Storrow, Alan B. A2 - Thurman, R. Jason PY - 2021 T2 - The Atlas of Emergency Medicine, 5e AB - Erythema nodosum (EN) can present at any age but is most common in young, adult females. Most typical is bilateral, erythematous, subcutaneous, tender nodules on the pretibial and lateral lower extremities (usually spares the posterior calves). Rarely, the nodules can be found on the thighs, upper extremities, and face. Concomitant symptoms include lower extremity edema and arthralgias. Systemic symptoms can include fever, headache, and gastrointestinal complaints. Generally, the nodules resolve over days to weeks with flattening and a change in color to a blue-green (like a deep bruise). There is no ulceration, and the skin slowly returns to normal. Recurrence occurs in up to one-third of cases. SN - PB - McGraw-Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1181043967 ER -