TY - CHAP M1 - Book, Section TI - Antiviral Drugs A1 - Levinson, Warren A1 - Chin-Hong, Peter A1 - Joyce, Elizabeth A. A1 - Nussbaum, Jesse A1 - Schwartz, Brian PY - 2020 T2 - Review of Medical Microbiology & Immunology: A Guide to Clinical Infectious Diseases, 16e AB - Compared with the number of drugs available to treat bacterial infections, the number of antiviral drugs is very small. The major reason for this difference is the difficulty in obtaining selective toxicity against viruses; their replication is intimately involved with the normal synthetic processes of the cell. Despite the difficulty, several virus-specific replication steps have been identified that are the site of action of effective antiviral drugs (Table 35–1). Table 35–2 describes the mode of action of antiviral drugs that block early events in viral replication, and Table 35–3 describes the mode of action of antiviral drugs that block viral nucleic acid synthesis. Figure 35–1 shows the replication of a model virus and the site of action of drugs used to treat various viral infections. Figure 35–2 shows the replication of human immunodeficiency virus (HIV) and the site of action of drugs used to treat HIV infection. SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1175828812 ER -