TY - CHAP M1 - Book, Section TI - Pulmonary Vasculitis A1 - Chesnutt, Asha N. A1 - Chesnutt, Mark S. A1 - Prendergast, Niall T. A1 - Prendergast, Thomas J. A2 - Papadakis, Maxine A. A2 - McPhee, Stephen J. A2 - Rabow, Michael W. PY - 2021 T2 - Current Medical Diagnosis & Treatment 2021 AB - Granulomatosis with polyangiitis is an idiopathic disease manifested by a combination of glomerulonephritis, necrotizing granulomatous vasculitis of the upper and lower respiratory tracts, and varying degrees of small-vessel vasculitis. Chronic sinusitis, arthralgias, fever, skin rash, and weight loss are frequent presenting symptoms. Specific pulmonary complaints occur less often. The most common sign of lung disease is nodular pulmonary infiltrates, often with cavitation, seen on chest radiography. Tracheal stenosis and endobronchial disease are sometimes seen. The diagnosis is most often based on serologic testing and biopsy of lung, sinus tissue, or kidney with demonstration of necrotizing granulomatous vasculitis (Chapter 20). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2023/03/23 UR - accessmedicine.mhmedical.com/content.aspx?aid=1175807975 ER -