TY - CHAP M1 - Book, Section TI - MONOAMINE OXIDASE INHIBITORS A1 - Benowitz, Neal L. A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. PY - 2018 T2 - Poisoning & Drug Overdose, 7e AB - Most monoamine oxidase (MAO) inhibitors are used primarily for severe depression resistant to other antidepressant drugs, but are also used to treat phobias and anxiety disorders. First-generation MAO inhibitors include isocarboxazid (Marplan), phenelzine (Nardil), and tranylcypromine (Parnate). Newer-generation MAO inhibitors with lower toxicity include selegiline (Eldepryl, Emsam, Zelapar) and rasagiline (Azilect), also used in the treatment of Parkinson's disease, and moclobemide (Aurorix, Manerix), a much less toxic antidepressant that is available in many countries, but not in the United States. Multiple other MAO inhibitors are marketed outside the United States to treat depression, anxiety disorders, Parkinson's disease, and bacterial infections. Serious toxicity from MAO inhibitors occurs with overdose or owing to interactions with certain other drugs or foods (Table II–41). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174606516 ER -