TY - CHAP M1 - Book, Section TI - DISULFIRAM A1 - Geller, Richard J. A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. PY - 2018 T2 - Poisoning & Drug Overdose, 7e AB - Disulfiram (tetraethylthiuram disulfide [CASRN 97-77-8], or Antabuse) is an antioxidant industrial chemical produced since 1881 for the vulcanization of rubber. Introduced in the 1930s into clinical medicine as a vermicide and scabicide, it has been used in the United States since 1951 as a drug in the treatment of alcoholism. Ingestion of ethanol while taking disulfiram causes a well-defined unpleasant reaction, the fear of which provides a negative incentive to drink alcohol. Clinical toxicity is caused by overdose or occurs as a result of a disulfiram–ethanol drug interaction. Disulfiram is being investigated for the treatment of cocaine addiction, drug-resistant fungal infections, and malignancies. The toxicities resulting from disulfiram overdose differ from those of disulfiram–ethanol interaction. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174605803 ER -