TY - CHAP M1 - Book, Section TI - CLONIDINE AND RELATED DRUGS A1 - Rangan, Cyrus A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. PY - 2018 T2 - Poisoning & Drug Overdose, 7e AB - Clonidine and the related centrally acting adrenergic inhibitors guanabenz, guanfacine, and methyldopa are commonly used for the treatment of hypertension. Clonidine also has been used to alleviate opioid and nicotine withdrawal symptoms. Clonidine overdose may occur after ingestion of pills or ingestion of the long-acting skin patches. Oxymetazoline, naphazoline, and tetrahydrozoline are nasal and conjunctival decongestants that may cause toxicity identical to that of clonidine. Tizanidine is a chemically related agent used for the treatment of muscle spasticity. Apraclonidine and brimonidine, ophthalmic preparations for the treatment of glaucoma and ocular hypertension, may cause poisoning from ingestion and from systemic absorption after topical administration. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174605617 ER -