TY - CHAP M1 - Book, Section TI - CARBAMAZEPINE AND OXCARBAZEPINE A1 - Kearney, Thomas E. A2 - Olson, Kent R. A2 - Anderson, Ilene B. A2 - Benowitz, Neal L. A2 - Blanc, Paul D. A2 - Clark, Richard F. A2 - Kearney, Thomas E. A2 - Kim-Katz, Susan Y. A2 - Wu, Alan H. B. PY - 2018 T2 - Poisoning & Drug Overdose, 7e AB - Carbamazepine (Tegretol), an iminostilbene compound, was introduced in the United States in 1974 for the treatment of trigeminal neuralgia. It has become a first-line drug for the treatment of generalized and partial complex seizure disorders and has found expanded use for pain syndromes, psychiatric illnesses, and drug withdrawal reactions. Oxcarbazepine (Trileptal) was approved by the US FDA in 2000 and is the 10-keto analog of carbamazepine. It is considered a prodrug with a principal metabolite, 10,11-dihydro-10-hydroxycarbazepine (monohydroxy derivative [MHD]) that is responsible for its principal therapeutic and toxic effects, which are similar to those of carbamazepine. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1174605451 ER -