TY - CHAP M1 - Book, Section TI - Neurophysiology and Pharmacology of the Lower Urinary Tract A1 - Andersson, Karl-Erik A2 - McAninch, Jack W. A2 - Lue, Tom F. PY - 2020 T2 - Smith & Tanagho's General Urology, 19e AB - The bladder, in concert with the urethra and the pelvic floor, is responsible for storage and periodic expulsion of urine. The integrated function of these components of the lower urinary tract (LUT) is dependent on a complex control system in the brain, spinal cord, and peripheral ganglia, and on local regulatory factors (de Groat and Yoshimura, 2001, 2006, 2015). Dysfunction of the central nervous control systems or of the components of the LUT can produce voiding difficulties and retention of urine, or different types of urinary incontinence (mainly urgency and stress incontinence), or the symptom complex of the “overactive bladder” (OAB), characterized by urgency and frequency with or without urgency incontinence, often with nocturia (Abrams et al, 2002). SN - PB - McGraw Hill CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1171184633 ER -