TY - CHAP M1 - Book, Section TI - Azotemia and Urinary Abnormalities A1 - Jameson, J. Larry A1 - Fauci, Anthony S. A1 - Kasper, Dennis L. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Loscalzo, Joseph PY - 2020 T2 - Harrison's Manual of Medicine, 20e AB - Azotemia is the retention of nitrogenous waste products excreted by the kidney. Increased levels of blood urea nitrogen (BUN) (>10.7 mmol/L [>30 mg/dL]) and creatinine (>133 µmol/L [>1.5 mg/dL]) are ordinarily indicative of impaired renal function. Renal function can be estimated by determining the clearance of creatinine (CLcr) (normal >100 mL/min); this can be directly measured from a 24-h urine collection using the following equation: SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1167063389 ER -