TY - CHAP M1 - Book, Section TI - Sepsis and Septic Shock A1 - Jameson, J. Larry A1 - Fauci, Anthony S. A1 - Kasper, Dennis L. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Loscalzo, Joseph PY - 2020 T2 - Harrison's Manual of Medicine, 20e AB - Sepsis: a life-threatening organ dysfunction caused by a dysregulated host response to infection.Septic shock: a subset of sepsis in which underlying circulatory and cellular/metabolic abnormalities lead to substantially increased mortality risk. Pts need vasopressor therapy to elevate mean arterial pressure to ≥65 mmHg with a serum lactate concentration >2.0 mmol/L despite adequate fluid resuscitation. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/20 UR - accessmedicine.mhmedical.com/content.aspx?aid=1167062579 ER -