TY - CHAP M1 - Book, Section TI - Acid-Base Disorders A1 - Jameson, J. Larry A1 - Fauci, Anthony S. A1 - Kasper, Dennis L. A1 - Hauser, Stephen L. A1 - Longo, Dan L. A1 - Loscalzo, Joseph PY - 2020 T2 - Harrison's Manual of Medicine, 20e AB - Regulation of normal pH (7.35–7.45) depends on both the lungs and kidneys. By the Henderson-Hasselbalch equation, pH is a function of the ratio of HCO3− (regulated by the kidney) to PCO2 (regulated by the lungs). The HCO3/PCO2 relationship is useful in classifying disorders of acid-base balance. Acidosis is due to gain of acid or loss of alkali; causes may be metabolic (fall in serum HCO3−) or respiratory (rise in PCO2). Alkalosis is due to loss of acid or addition of base and is either metabolic (↑ serum [HCO3−]) or respiratory (↓ PCO2) (Fig. 2-1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1167062322 ER -