TY  - CHAP
M1  - Book, Section
TI  - Acquired Disorders of Coagulation
A1  - Leavitt, Andrew D.
A1  - Minichiello, Tracy
A2  - Papadakis, Maxine A.
A2  - McPhee, Stephen J.
A2  - Rabow, Michael W.
PY  - 2020
T2  - Current Medical Diagnosis and Treatment 2020
AB  - Patients  with  antiphospholipid  antibodies  occasionally  have  antibody  specificity  to  coagulation  factor  II  (prothrombin),  leading  typically  to  a  severe  hypoprothrombinemia  and  bleeding.  Mixing  studies  may  or  may  not  reveal  presence  of  an  inhibitor,  as  the  antibody  typically  binds  a  non-enzymatically  active  portion  of  the  molecule  that  leads  to  accelerated  clearance,  but  characteristically  the  PT  is  prolonged  and  levels  of  factor  II  are  low.  FFP  should  be  administered  for  treatment  of  bleeding.  Treatment  is  immunosuppressive.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2022/05/28
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1166166693
ER  -