TY  - CHAP
M1  - Book, Section
TI  - Hereditary Disorders of Genome Instability and DNA Repair
A1  - DiGiovanna, John J.
A1  - Rünger, Thomas M.
A1  - Kraemer, Kenneth H.
A2  - Kang, Sewon
A2  - Amagai, Masayuki
A2  - Bruckner, Anna L.
A2  - Enk, Alexander H.
A2  - Margolis, David J.
A2  - McMichael, Amy J.
A2  - Orringer, Jeffrey S.
PY  - 2019
T2  - Fitzpatrick's Dermatology, 9e
AB  - AT-A-GLANCEGenome  instability  characterizes  a  large  group  of  inherited  disorders  with  prominent  cutaneous  abnormalities;  many  have  an  increased  cancer  risk.Genome  instability  is  caused  by  impaired  repair  and/or  maintenance  of  DNA.Xeroderma  pigmentosum  is  a  prototype  with  impaired  repair  of  environmentally  induced  DNA  damage  and  a  greatly  increased  frequency  of  sunlight-induced  cancer.Although  these  disorders  are  rare,  heterozygous  carriers  of  affected  genes,  which  may  comprise  several  percent  of  the  general  population,  may  carry  an  increased  cancer  risk  as  well.  
SN  - 
PB  - McGraw-Hill Education
CY  - New York, NY
Y2  - 2024/04/20
UR  - accessmedicine.mhmedical.com/content.aspx?aid=1161339258
ER  -