TY - CHAP M1 - Book, Section TI - Cutaneous Necrotizing Venulitis A1 - Soter, Nicholas A. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEThe signature lesions of cutaneous necrotizing venulitis (CNV) are palpable purpura, erythematous to violaceous papules that do not blanch when the skin is pressed.Palpable purpura persist for 1 to 4 weeks and resolve at times with transient hyperpigmentation and/or atrophic scars.CNV may be associated with episodes of recurrent and chronic urticaria and angioedema.Lesions may occur anywhere on the skin but are most common on the lower extremities or over dependent areas such as the back and gluteal regions.CNV may be associated with connective tissue diseases, malignant conditions, cryoglobulinemia, antineutrophil cytoplasmic or antiphospholipid antibody syndromes.CNV has many precipitating causes, but infections and drugs are most common.The most widely recognized subgroup of idiopathic cutaneous necrotizing vasculitis in children is immunoglobulin A vasculitis.Histopathologic criteria include necrosis of the blood vessels with the deposition of fibrinoid material and dermal cellular infiltrates that consist of neutrophils with nuclear debris, mononuclear cells, and extravasated erythrocytes.Therapeutic approaches are divisible into removal of antigen, treatment of any underlying disorder, and treatment of CNV. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/29 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161349696 ER -