TY - CHAP M1 - Book, Section TI - Mucous Membrane Pemphigoid A1 - Yancey, Kim B. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCEA chronic autoimmune subepithelial blistering disease characterized by erosive lesions of mucous membranes and skin that typically results in scarring in at least some sites of involvement.Lesions commonly involve the oral and ocular mucosae; other sites that may be involved include the nasopharyngeal, laryngeal, esophageal, and anogenital mucosae.A rare disorder with a predominance in the elderly and an estimated incidence of 1 to 2 cases per million annually; females are affected 1.5 to 2 times as often as males.A progressive disorder that may result in serious complications (eg, blindness, loss of the airway, esophageal stricture formation).Severity of involvement in one organ does not necessarily correlate with the presence or severity of disease at other sites.Immunopathologic studies of perilesional mucosa and skin demonstrate in situ deposits of immunoreactants in epithelial basement membranes; circulating anti–basement membrane autoantibodies are detected in the sera of some but not all patients.A variety of different autoantigens are recognized by autoantibodies from patients, suggesting that mucous membrane pemphigoid is not a single nosologic entity but a disease phenotype. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/10/11 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161331618 ER -