TY - CHAP M1 - Book, Section TI - Soluble Mediators of the Cutaneous Immune System A1 - Ho, Allen W. A1 - Kupper, Thomas S. A2 - Kang, Sewon A2 - Amagai, Masayuki A2 - Bruckner, Anna L. A2 - Enk, Alexander H. A2 - Margolis, David J. A2 - McMichael, Amy J. A2 - Orringer, Jeffrey S. PY - 2019 T2 - Fitzpatrick's Dermatology, 9e AB - AT-A-GLANCECytokines are polypeptide mediators that function in communication between hematopoietic cells and other cell types.Cytokines often have multiple biologic activities (pleiotropism) and overlapping biologic effects (redundancy).Chemokines and their receptors are vital mediators of cellular trafficking.Chemokines are synthesized constitutively in some cells and can be induced in many other cell types.Cytokine and chemokine-based therapeutics now in use include recombinant cytokines, inhibitory monoclonal antibodies, fusion proteins composed of cytokine receptors and immunoglobulin chains, topical immunomodulators such as imiquimod, prevention of T-cell arrest on activated endothelium or blocking infection of T cells by human immunodeficiency virus 1 using CC chemokine receptor 5 analogs, and cytokine fusion toxins. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1161321278 ER -