TY - CHAP M1 - Book, Section TI - The Pathophysiology of Traumatic Brain Injury A1 - Watts, Lora Talley A1 - Jaramillo, Carlos A. A1 - Eapen, Blessen C. A2 - Mitra, Raj PY - 2019 T2 - Principles of Rehabilitation Medicine AB - Traumatic brain injury (tbi) is classically defined as an insult to the brain caused by an external physical force with a resulting alteration in brain function. The insult can be the result of blunt trauma, penetrating, acceleration-deceleration, or blast wave injuries. The result of such an impact varies highly from patient to patient and has been correlated with the severity of injury.1 TBI is considered a leading cause of death and long-term disability worldwide and affects all age groups and genders; however, children and the elderly are often considered at a higher risk of experiencing a TBI.2 Despite the tremendous effort invested in TBI research, the ability to minimize chronic neurologic deficits in TBI patients has remained extremely limited. This is likely a result of the vast complexity of the pathophysiology of a TBI. In fact, it is necessary to continue to explore and understand the underlying mechanisms of a TBI and how these mechanisms relate to functional outcomes. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1162856106 ER -