TY - CHAP M1 - Book, Section TI - The Thyroid Gland A1 - Barrett, Kim E. A1 - Barman, Susan M. A1 - Brooks, Heddwen L. A1 - Yuan, Jason X.-J. PY - 2019 T2 - Ganong's Review of Medical Physiology, 26e AB - OBJECTIVESAfter studying this chapter, you should be able to:Describe the development, anatomy, and histology of the thyroid gland, and how these relate to its function, as well as the changes in histology that accompany the activation of secretion with reabsorption of thyroglobulin from the colloid.Define the chemical nature of the thyroid hormones and how they are synthesized. Understand the critical role of iodine in the thyroid gland and how its transport is controlled, as well as how it is incorporated into the tyrosine residues of thyroglobulin at the interface between thyrocytes and colloid via the process of organification.Describe the relative roles of binding to albumin, transthyretin, and thyroxine-binding globulin in the transport of thyroid hormones, the availability of free hormones, and peripheral metabolism.Identify the role of the hypothalamus and pituitary in regulating thyroid function and the feedback loops that establish the level of secretion of thyroid hormones.Define the effects of the thyroid hormones in homeostasis, metabolism, and growth.Understand the basis of conditions where thyroid function is abnormal and how they can be treated. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1159053161 ER -