TY - CHAP M1 - Book, Section TI - Disorders of the Endocrine Pancreas A1 - Funk, Janet L. A2 - Hammer, Gary D. A2 - McPhee, Stephen J. PY - 2019 T2 - Pathophysiology of Disease: An Introduction to Clinical Medicine, 8e AB - Insulin and glucagon, the two key hormones that orchestrate fuel storage and use, are produced by the islet cells in the pancreas. Islet cells are distributed in clusters throughout the exocrine pancreas. Together, they comprise the endocrine pancreas. Diabetes mellitus, a heterogeneous disorder, is the most common disease of the endocrine pancreas. Affecting 9% of the world’s adult population in 2014, the prevalence of diabetes continues to increase worldwide, having already more than doubled over the past three decades. Pancreatic tumors secreting excessive amounts of specific islet cell hormones are far less common, but their clinical presentations underscore the important regulatory roles of each hormone. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1156659591 ER -