TY - CHAP M1 - Book, Section TI - Severe Acute Encephalopathies and Critical Care Weakness A1 - Hemphill, III, J. Claude A1 - Smith, Wade S. A1 - Josephson, S. Andrew A1 - Gress, Daryl R. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Life-threatening neurologic illness may be caused by a primary disorder affecting any region of the neuraxis or may occur as a consequence of a systemic disorder such as hepatic failure, multisystem organ failure, or cardiac arrest (Table 301-1). Neurologic critical care focuses on preservation of neurologic tissue and prevention of secondary brain injury caused by ischemia, hemorrhage, edema, herniation, and elevated intracranial pressure (ICP). Encephalopathy is a general term describing brain dysfunction that is diffuse, global, or multi-focal. Severe acute encephalopathies represent a group of various disorders due to different neurological or systemic etiologies, but that share the common themes of primary and secondary brain injury. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/19 UR - accessmedicine.mhmedical.com/content.aspx?aid=1181485903 ER -