TY - CHAP M1 - Book, Section TI - Polymorphic Ventricular Tachycardia and Ventricular Fibrillation A1 - John, Roy M. A1 - Stevenson, William G. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Sustained polymorphic VT can be seen with any form of structural heart disease. However, unlike sustained monomorphic VT, polymorphic VT does not always indicate a structural abnormality or focus of automaticity. Reentry with continually changing reentrant paths, spiral wave reentry and multiple automatic foci are potential mechanisms (Chap. A9). Sustained polymorphic VT usually degenerates into ventricular fibrillation (VF). Polymorphic VT is typically seen in association with acute myocardial infarction or ischemia (MI), ventricular hypertrophy, and a number of genetic mutations that affect cardiac ion channels (see Table 249-1). SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/04/16 UR - accessmedicine.mhmedical.com/content.aspx?aid=1156562517 ER -