TY - CHAP M1 - Book, Section TI - Non-Hodgkin’s Lymphoma A1 - Jacobson, Caron A. A1 - Longo, Dan L. A2 - Jameson, J. Larry A2 - Fauci, Anthony S. A2 - Kasper, Dennis L. A2 - Hauser, Stephen L. A2 - Longo, Dan L. A2 - Loscalzo, Joseph PY - 2018 T2 - Harrison's Principles of Internal Medicine, 20e AB - Non-Hodgkin’s lymphomas (NHL) are cancers of mature B, T, and NK cells. They were distinguished from Hodgkin lymphoma (HL) upon recognition of the Reed-Sternberg (RS) cell, and differ from HL with respect to their biologic and clinical characteristics. Whereas ~80–85% of patients with HL will be cured of their lymphoma by chemotherapy with or without radiotherapy, the prognosis and natural history of NHL tends to be more variable. NHL can be classified as either a mature B-NHL, or a mature T/NK-NHL depending on whether the cancerous lymphocyte is a B, T, or NK-cell, respectively. Within each category are lymphomas that grow quickly and behave aggressively, as well as lymphomas that are more indolent, or slow growing in nature. For a list of the World Health Organization (WHO) classification of lymphoid neoplasms, see Table 104-1. SN - PB - McGraw-Hill Education CY - New York, NY Y2 - 2024/03/28 UR - accessmedicine.mhmedical.com/content.aspx?aid=1180837238 ER -